H2N2V1, Main, Exploration, bibRecord, 002A58

Pilot Studies on Recombinant Cold-Adapted Live Type A and B Influenza Virus Vaccines

Identifieur interne : 002A58 ( Main/Exploration ); précédent : 002A57; suivant : 002A59

Pilot Studies on Recombinant Cold-Adapted Live Type A and B Influenza Virus Vaccines

Auteurs : Fred M. Davenport [États-Unis] ; Albert V. Hennessy ; Hunein F. Maassab ; Elva Minuse ; Larry C. Clark ; Gerald D. Abrams ; John R. Mitchell

Source :

Journal of Infectious Diseases [ 0022-1899 ] ; 1977.

RBID : ISTEX:555DAEDA3B97BE99B5A522FBD0C60F25C507C2C8

Abstract

Recombinant live attenuated type A and B influenza virus vaccines derived from standardized cold-adapted parent strains were given singly and in combination to volunteers. The vaccine viruses were well tolerated, functioned as good antigens, and failed to spread to intimate household contacts. Thirty-nine isolates that were recovered after a single passage in humans appeared genetically stable. The results of histopathologic studies in ferrets encourage development of an animal model for attenuation of the virus.

Url:

https://api.istex.fr/ark:/67375/HXZ-MHTQZPT4-N/fulltext.pdf

DOI: 10.1093/infdis/136.1.17

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: 001528
to stream Istex, to step Curation: 001528
to stream Istex, to step Checkpoint: 001636
to stream Main, to step Merge: 002C19
to stream Main, to step Curation: 002A58

Le document en format XML

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<author><name sortKey="Hennessy, Albert V" sort="Hennessy, Albert V" uniqKey="Hennessy A" first="Albert V." last="Hennessy">Albert V. Hennessy</name>
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<author><name sortKey="Maassab, Hunein F" sort="Maassab, Hunein F" uniqKey="Maassab H" first="Hunein F." last="Maassab">Hunein F. Maassab</name>
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<author><name sortKey="Minuse, Elva" sort="Minuse, Elva" uniqKey="Minuse E" first="Elva" last="Minuse">Elva Minuse</name>
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<author><name sortKey="Clark, Larry C" sort="Clark, Larry C" uniqKey="Clark L" first="Larry C." last="Clark">Larry C. Clark</name>
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<author><name sortKey="Abrams, Gerald D" sort="Abrams, Gerald D" uniqKey="Abrams G" first="Gerald D." last="Abrams">Gerald D. Abrams</name>
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<placeName><region type="state">Michigan</region>
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<wicri:cityArea>Please address requests for reprints to Dr. Fred M. Davenport, Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor</wicri:cityArea>
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<author><name sortKey="Mitchell, John R" sort="Mitchell, John R" uniqKey="Mitchell J" first="John R." last="Mitchell">John R. Mitchell</name>
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<series><title level="j" type="main">Journal of Infectious Diseases</title>
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<front><div type="abstract">Recombinant live attenuated type A and B influenza virus vaccines derived from standardized cold-adapted parent strains were given singly and in combination to volunteers. The vaccine viruses were well tolerated, functioned as good antigens, and failed to spread to intimate household contacts. Thirty-nine isolates that were recovered after a single passage in humans appeared genetically stable. The results of histopathologic studies in ferrets encourage development of an animal model for attenuation of the virus.</div>
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<name sortKey="Minuse, Elva" sort="Minuse, Elva" uniqKey="Minuse E" first="Elva" last="Minuse">Elva Minuse</name>
<name sortKey="Mitchell, John R" sort="Mitchell, John R" uniqKey="Mitchell J" first="John R." last="Mitchell">John R. Mitchell</name>
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<country name="États-Unis"><region name="Michigan"><name sortKey="Davenport, Fred M" sort="Davenport, Fred M" uniqKey="Davenport F" first="Fred M." last="Davenport">Fred M. Davenport</name>
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Pilot Studies on Recombinant Cold-Adapted Live Type A and B Influenza Virus Vaccines

Pilot Studies on Recombinant Cold-Adapted Live Type A and B Influenza Virus Vaccines

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri